Anticoagulants

SOF

* Anticoagulants prevent blood clotting (both in vivo and in vitro)

* Some anticoagulants are only used in vivo

* Anticoagulants used in vivo are often termed "blood thinners"

Some anticoagulants are only used in vitro

* In vitro anticoagulants are not interchangeable (in some cases)

* Heparin is an anticoagulant used both in vivo and in vitro

* Heparin has a half-life of 1.5 hours

* Sodium citrate is
an anticoagulant used in vitro


* EDTA
is an anticoagulant used in vitro


* EDTA stands for ethylenediaminetetraacetic acid

* EDTA binds calcium and prevents its use in the clotting cascade

* Coumarins are orally active (in vivo) anticoagulants

* Warfarin is the most famous coumarin anticoagulant

* Coumarins are vitamin K antagonists

* Vitamin K is an antidote for moldy sweet clover disease (cattle)


EL

* Heparin-1

* Heparin-2

* Sodium Citrate-1

* Sodium Citrate-2

* EDTA-1

* EDTA-2-Other Uses

* Warfarin-1

* Warfarin-2

* Blood Specimen Collection and Processing