Blood Brain Barrier


* The barrier is formed by capillary endothelial cells in the brain

* The interface between endothelial cells and respective brain tissue is therefore the BBB

* Most capillaries in the body are leaky

* Brain capillaries are not leaky

Tight junctions between brain endothelial cells restricts passage of most material

The BBB protects the brain from harmful substances

* Some lipid-soluble material can cross the BBB

* Glucose transporter proteins carry glucose into brain tissue

* Circumventricular organs (tissue) do not have an intact BBB

* Circumventricular organs include pineal, vomition center, neurohypophysis, and median eminence

Hypertension disrupts the BBB

* The BBB is not fully formed at birth


* BBB-Wikipedia


* BBB-image1

* BBB-image2

* BBB-image3